Rapid production of acute disseminated encephalomyelitis in rhesus monkeys by injection of brain tissue with adjuvants.
نویسندگان
چکیده
Rapid production in the monkey of a pathological condition resembling acute disseminated encephalomyelitis, marked by demyelination, can be achieved by the use of adjuvants added to rabbit brain emulsions.
منابع مشابه
The Rapid Production of Acute Disseminated Encephalomyelitis in Rhesus Monkeys by Injection of Heterologous and Homologous Brain Tissue with Adjuvants
1. A picture resembling acute disseminated encephalomyelitis in the human being has been regularly and rapidly produced in rhesus monkeys by injection of emulsions of adult rabbit and monkey brain administered with adjuvants. 2. No lesions of the central nervous system resulted from injection of similar emulsions of fetal rabbit brain or adult rabbit lung. 3. A description of the gross and hist...
متن کاملStudies on Acute Disseminated Encephalomyelitis Produced Experimentally in Rhesus Monkeys
Acute disseminated encephalomyelitis has been produced in rhesus monkeys by injection of their own brain tissue, removed surgically and incorporated with adjuvants.
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Multiple lesions of the central nervous system characterized by their wide dissemination, predilection for the white matter, perivascular position, inflammation, proliferation of histiocytes, giant cell formation, and associated demyelination, have been produced in several laboratories by intramuscular injection into monkeys of emulsions and extracts of rabbit brain (1-3). The procedure, howeve...
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By subcutaneous injection of central nervous tissue emulsified with adjuvants according to Freund's technique it has been possible to induce in the majority of monkeys an acute disseminated encephalomyelitis which is interpreted as an isoimmunization to CNS tissue. Positive reactions occurred only in response to CNS tissue containing white matter; i.e., cerebral white matter, spinal cord (wheth...
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Acute disseminated encephalomyelitis (ADEM) is a monophasic clinical syndrome, characterized by immune-mediated demyelination of central nervous system neurons, which yield extensive damage in the brain and spinal cord.It usually affects children and young adults following infections or immunization. Here we describe a 9- year-old Fars female presented with acute onset of psychotic disorder, o...
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ورودعنوان ژورنال:
- Science
دوره 104 2703 شماره
صفحات -
تاریخ انتشار 1946